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Poliovirus is the causative agent of poliomyelitis, which causes the degradation of the myelin sheaths of the Central Nervous System. Those who have polio usually lose their ability to walk and do other activities of daily living. 1DGI is a protein that is a precursor of the human poliovirus. Its structure is quartenary because it has 2 subunits. 1DGI does not cause poliovirus or necessarily mean that someone will have poliovirus.